摘要
目的:探讨食管鳞癌中Survivin的表达及其临床病理学意义。方法:通过免疫组织化学SP法对80例食管鳞癌及20例正常食管组织中Survivin的表达情况进行检测。结果:80例食管鳞癌Survivin表达阳性率为65%,20例正常食管组织中未见Survivin的表达。Survivin表达阳性率与癌组织分化程度、淋巴结转移、TNM分期呈正相关(P<0.05)。结论:Survivin在食管鳞癌中高表达,可能参与食管癌的发生、发展过程。
Objective:To investigate the expression of Survivin and its clinicopathologic significance in Esophageal Squamous Cell Carcinoma (ESCC). Methods: The immunohistochemistry assay was used to measure the expression of Sur- vivin in 80 cases of ESCC and 40 normal esophageal tissues. Results: The positive rates of Survivin expressions were 65% in ESCC, and negative rates were found in all normal esophageal tissues. The positive expressions of Survivin had a posi- tive correlation with the degrees of differentiation, lymph node metastasis and clinical stages. Conclusions: Survivin was more highly expressed in ESCC than in normal esophageal tissues, which may be involved in the Carcinogenesis and de- velopment process of ESCC.
出处
《交通医学》
2013年第6期614-616,共3页
Medical Journal of Communications