Survivin在食管鳞癌中的表达及其意义

The expression and clinicopathologic signification of Survivin in Esophageal Squamous Cell Carcinoma

目的:探讨食管鳞癌中Survivin的表达及其临床病理学意义。方法:通过免疫组织化学SP法对80例食管鳞癌及20例正常食管组织中Survivin的表达情况进行检测。结果:80例食管鳞癌Survivin表达阳性率为65%,20例正常食管组织中未见Survivin的表达。Survivin表达阳性率与癌组织分化程度、淋巴结转移、TNM分期呈正相关(P<0.05)。结论:Survivin在食管鳞癌中高表达,可能参与食管癌的发生、发展过程。

Objective：To investigate the expression of Survivin and its clinicopathologic significance in Esophageal Squamous Cell Carcinoma （ESCC）. Methods： The immunohistochemistry assay was used to measure the expression of Sur- vivin in 80 cases of ESCC and 40 normal esophageal tissues. Results： The positive rates of Survivin expressions were 65% in ESCC, and negative rates were found in all normal esophageal tissues. The positive expressions of Survivin had a posi- tive correlation with the degrees of differentiation, lymph node metastasis and clinical stages. Conclusions： Survivin was more highly expressed in ESCC than in normal esophageal tissues, which may be involved in the Carcinogenesis and de- velopment process of ESCC.