补肾活血中药治疗多囊卵巢综合征导致排卵障碍性不孕的临床研究

Clinical efficacy observation on therepy ovulation failure infertility caursed by PCOS with reinforcing kidney,activating blood circulation and ovarian stimulation compound recipe

为探讨补肾活血促卵方治疗多囊卵巢综合征导致排卵障碍性不孕的临床疗效，由中国中医科学院西苑医院及中国中医科学院中医门诊部将符合纳入标准的60个病例，随机分为治疗组、对照组。治疗组服用补肾活血促卵方（菟丝子15g、桑寄生15g、川断15g、枸杞子15g、女贞子10g、鸡血藤15g、泽兰15g,蒲黄10g、当归10g、川牛膝15g、益母草15g、赤芍15g、丹参15g等），对照组服用克罗米芬。通过1～2个疗程的治疗，治疗组妊娠率为56．67％，排卵率61．00％；对照组妊娠率为30．00％，排卵率72．84％。组间比较均有显著性差异（P〈0．05），妊娠率治疗组优于对照组。治疗组对FSH，LH及其比值有调节性作用，并且升高E2水平，有效降低T，PRL，INS等激素水平，有助于成熟卵泡的发育及子宫内膜生长，提高排卵率及妊娠率。对照组对FSH，E2有增高的趋势，对LH，T，PRL及INS作用均不明显。

To investigate the clinical effect of tonifying the kidney and promoting blood circulation to promote ooeyte decoction in the treatment of anovulatory infertility caused by polycystic ovary syndrome. Sixty cases were selected from the out-patient department of Xiyuan hospital of China academy of Chinese medical sciences and the Chinese academy of traditional Chinese medicine, Chinese medicine out-patient department. Sixty patients with PCOS patients were randomly divided into the treatment group and the control group, with 30 cases and 30 cases respectively. The treatment group was given decoction of the reinforcing kidney, activating blood circulation and ovarian stimulation compound recipe. The control group was treated with clomiphene. Through the treatment of 1-2 courses, in the treatment group the pregnancy rate was 56. 67%, the ovulation rate 61% ; in control group of clomiphene citrate ovulation ratepregnancy rate was 30%, 72. 84% of ovulation rate. The difference was significant between two groups （ P 〈 0. 05 ）, the pregnancy rate in the treatment group was higher than the control group. The treatment group has regulatory effect on FSH, LH and their ratio, and increase E2 level, decrease T, PRL, INS and other hormone levels, contributing to the mature development of the follicles and endometrium growth, increase the ovulation rate and pregnancy rate. The control group on FSH, E2 increased, LH, T, PRL and INS showed no obvious effect.