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NLRP3炎症小体与肺部疾病 被引量：4

NLRP3 inflammasome and pulmonary diseases
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摘要 NLRP3炎症小体是细胞内固有免疫系统的感受器，是-类通过活化caspase-1来间接调控IL-18与IL-18的成熟和分泌的蛋白复合体。作为机体固有免疫及应激系统的重要防御成分，NLRP3炎症小体参与了多种疾病发生和进展。近年发现NLRP3炎症小体与肺部疾病关系密切。本文就NLRP3炎症小体的组成、活化机制及其在肺炎、肺结核、COPD及哮喘等肺部疾病中的研究作一综述。 NLRP3 inflammasome is a class of protein complexes which regulates the maturation of proinflammatory cytokines including IL-1β and IL-18 through activation of caspase-1. As part of the innate immune and stress defense system, NLRP3 inflammasome is participated in the occurenee and progression of many diseases. Recent studies have found that NLRP3 inflammasome has close relationship with pulmonary diseases. In this paper, the composition and the activation mechanism of NLRP3 inflammasome and the role of NLRP3 inflammasome in the pathogenesis of pneumonia, tuberculosis, chronic obstructive pulmonary disease,and asthma are reviewed.
作者 王金凤 刘晓菊 曾晓丽
机构地区 兰州大学第一一医院老年呼吸科
出处 《国际呼吸杂志》 2014年第2期115-118,共4页 International Journal of Respiration
基金 国家自然科学基金（81070038）
关键词 NLRP3炎症小体 肺部疾病 白介素1Β 白介素18 炎症 NLRP3 inflammasome Pulmonary diseases Interleukin 1β Interleukin-18 Inflammation
分类号 R563 [医药卫生—呼吸系统]
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参考文献30

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同被引文献37

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国际呼吸杂志
2014年 第2期

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