NOS3 G894T基因多态性与肿瘤易感性的Meta分析

A Meta analysis on NOS3 G894T polymorphism and cancer susceptibility

目的探讨内皮型一氧化氮合酶(NOS3或eNOS)G894T基因多态性与肿瘤易感性的关系。方法通过计算机检索和手工检索,收集有关NOS3G894T基因多态性与肿瘤易感性的文献,筛选出符合纳入和排除标准的文献,应用Meta分析软件对各项研究进行异质性检验,计算合并OR值及其95%CI,并行敏感性分析和发表偏倚的评估。结果 19篇文献纳入本研究,共计有7 679例肿瘤患者和8 180例对照人群。总体来说,NOS3G894T基因多态性与肿瘤无明显易感性(T versus G:OR=1.030,95%CI0.964-1.101;TT versus GG:OR=1.056,95%CI 0.895-1.245;TG versus GG:OR=1.045,95%CI 0.977-1.119;TT/TG versus GG:OR=1.047,95%CI0.981-1.117;TT versus TG/GG:OR=1.005,95%CI0.900-1.123)。根据种族、肿瘤类型及对照组来源进行分层分析,没有发现有明显易感性。结论 NOS3G894T基因多态性与肿瘤不存在明显易感性。

Objective To investigate the relation between polymorphism of NOS3 G894T and susceptibility of cancer .Methods Literatures under the inclusion and exclusion criteria about relation between polymorphism of NOS 3 G894T and susceptibility of cancer were collected by computer -based retrieval and manual retrieval .The pools ORs with 95% CI were calculated to assess the association strength between polymorphism of NOS 3 G894T and cancer risk by Meta methods .Sensitivity and publication bias were evaluated .Results 19 literatures with 7679 cases of cancer and 8180 cases as control group were included .The pooled result indica-ted that no significant association between its polymorphism and cancer （ORT versus G=1 .030 ,95% CI=0 .964 -1 .101 ;ORTT versus GG=1 .056 ,95% CI=0 .895-1 .245 ;ORTG versus GG=1 .045 ,95% CI=0 .977-1 .119 ;ORTT/TG versus GG=1 .047 , 95% CI=0 .981-1 .117 ;ORTT versus TG/GG=1 .005 ,95% CI=0 .900-1 .123） .No significant association was observed in sub-group analysis based on ethnicity ,cancer type ,and source of control group .Conclusion There was no relationship between NOS3 G894T polymorphism and cancer susceptibility .