熊果酸液固压缩片的制备及优势

Preparation and Advantages of Ursolic Acid Liquid- Solid Compressed Tablets

目的优选制备熊果酸液固压缩片的处方并探讨其优势。方法用不同处方制备熊果酸液固压缩片,同时与普通片剂进行片剂质量和溶出度比较。结果液固压缩片较普通片剂的溶出度大幅度提高,在45 min时最多可提高214%;片剂质量在崩解时限、重量差异等方面均明显优于普通片剂,崩解时限至少缩短一半。结论液固压缩技术可应用于难溶性药物熊果酸的制剂,且具有一定优势。

Objective To prepare the prescription of Ursolic Acid Liquid- Solid Compressed Tablets and to explore its advantages. Methods The preparation of Ursolic Acid Liquid- Solid Compressed Tablets was investigated by different prescriptions. At the same time, its quality and dissolution rate were compared with those of the ordinary tablets. Results The dissolution rate of the liquid- solid compressed tablets was increased by a large margin than the ordinary tablets, which was increased by 214% in 45 min, at most by 214%. The compressed tablets quality is significantly superior to the ordinary tablets in the aspects of the disintegration time limit and the weight difference, etc. The disintegration time limit was cut in half th time. Conclusion The liquid- solid compression technique can be applied to the preparations of poorly soluble drug ursolic acid and has certain advantages.