糖皮质激素联合环磷酰胺治疗肾病综合征49例

Glucocorticoid Combined with Cyclophosphamide in Treating Nephrotic Syndrome in 49 Cases

目的观察糖皮质激素联合环磷酰胺治疗肾病综合征的效果。方法选取2011年至2012年收治的肾病综合征患者98例,随机分为两组,各49例,观察组给予糖皮质激素联合环磷酰胺治疗,对照组单纯给予糖皮质激素治疗,比较两组患者治疗前后6个月各项指标的变化、治疗效果及并发症。结果两组患者血白蛋白水平比治疗前均明显升高,24 h尿蛋白量及血肌酐较治疗前明显降低(P<0.05);治疗后观察组患者血白蛋白水平、24 h尿蛋白量及血肌酐均明显低于对照组患者,观察组患者的缓解率为89.90%,明显高于对照组的71.43%,但不良反应发生率高于对照组(P<0.05)。结论糖皮质激素联合环磷酰胺治疗肾病综合征效果明显,但不良反应较多。

Objective To investigate the effect of glucocorticoid combined with cyclophosphamide in treating nephrotic syndrome. Methods Ninety-eight patients with nephrotic syndrome admitted to our hospital from 2011 to 2012 were randomly divided into 2 groups. The observation group（49 cases） was given glucocorticoid combined with cyclophosphamide therapy, while the control groups （49 cases） was given glucocorticoid therapy alone. The changes of various indexes, therapeutic effects and complications before and after 6- month therapy were compared between the two groups. Results The blood albumin level after 6- month treatment in the two groups was increased significantly than before treatment, the 24 h urinary albumin amount and serum creatinine were significantly decreased than before treatment（P〈0. 05）, the blood albumin levels in the observation group after treatment was significantly higher than that in the control group, but the 24 h urinary albumin amount and serum creatinine were obviously lower than those in the control group, the remission rate of the observation group was 89.90%, which was significantly higher than 71.43% in the control group, the occurrence rate of adverse reactions in the observation group was higher than that in the control group（ P 〈 0. 05）. Conclusion Glucocorticoid combined with eyclophosphamide has significant effect in treating nephrotic syndrome, but there are many adverse reactions.