CD7在非淋巴造血组织中的表达

The expression of CD7 in nonhematopoietic tissues

目的探索CD7在非淋巴造血组织的表达情况,并总结其规律。方法收集北京友谊医院病理科多种不同组织切片283例,观察HE切片组织形态,应用免疫组织化学EliVision法对多组织芯片进行CD7筛查,然后与雌激素受体(ER)进行同切片的对比分析。结果 CD7在乳腺组织中51.15%(67/131)、子宫内膜组织中100%(18/18)、宫颈组织中100%(15/15)、输卵管组织中100%(2/2)、卵巢组织中44.4%(4/9)、前列腺组织中33.3%(1/3)出现细胞核阳性表达;其余数种组织均未出现CD7细胞核表达。CD7在非淋巴造血组织中的表达定位在细胞核,而不在细胞膜。ER在乳腺组织中53.44%(70/131)、子宫内膜组织中100%(18/18)、宫颈组织中100%(15/15)、输卵管组织中100%(2/2)、卵巢组织中33.3%(3/9)、前列腺组织中33.3%(1/3)出现细胞核阳性表达;其余数种组织均未出现ER表达。结论①CD7不仅可以在淋巴造血组织中表达,也可在一些非淋巴造血组织中表达;②CD7仅在非淋巴造血组织的细胞核中表达;③CD7与ER表达的组织类型基本吻合。

Objective To explore the expression of CD7 in nonhematopoietic tissues, then summarize its regular patterns. Methods Two hundred eighty - three different tissue samples obtained from Beijing Friendship Hospital were examined by Elivision immunohistochemical staining for CD7 and estrogen receptor （ER）. Results CD7 expression was four/d in mammary gland tissue （67 of 131,51.15% ）, endometrial tissue （ 18 of 18, 100% ）, cervix tissue （ 15 of 15, 100% ）, oviduct tissue （2 of 2, 100% ）, ovary tissue （4 of 9, 44.4% ） and prostate gland tissue （ 1 of 3,33.3% ）. Other tissues were CD7 negative. In addition, it is observed that CD7 expression in nonhematopoietic tissues was located in the nucleus but not the membrane of the cells. ER expression was found in mammary gland tissue （70 of 131,53.44% ）, endometrial tissue （ 18 of 18, 100% ）, cervix tissue （ 15 of 15, 100% ）, oviduct tissues （2 of 2, 100% ）, ovary tissue （3 of 9, 33.3% ） and prostate gland tissue （ 1 of 3, 33.3% ）. No ER expression was observed in other tissues. Conclusion ①CD7 expression is not only observed in the hematopoietic tis- sues, but also in the nonhematopoietic tissues. ②CD7 expression in the nonhematopoietic tissues is limited in the nucleus. ③Thc tissue types are basically the same for the expressions of CD7 and ER.