苯磺酸左旋氨氯地平和替米沙坦联合治疗原发性高血压

L-amlodipine and telmisartan combined treatrent of primary hypertemsion

目的观察以左旋氨氯地平为主的不同降压方案治疗原发性高血压的临床疗效。方法纳入139例患者,70例为联合应用苯磺酸左旋氨氯地平和替米沙坦治疗;69例为对照组单独应用苯磺酸左旋氨氯地平治疗;苯磺酸左旋氨氯地平2.5 mg,1次/d,替米沙坦40 mg,1次/d,用药1周后未能达到目标血压,则苯磺酸左旋氨氯地平增至5 mg,替米沙坦增至80 mg,服用6周评价药物的有效性和安全性。结果联合组治疗6周后总有效率为92.9%,对照组总有效率87.0%,且两组血压均比治疗前显著降低,差异有显著性意义(P<0.05)。结论联合应用苯磺酸左旋氨氯地平和替米沙坦治疗原发性高血压提高了疗效,并且安全。

Objective To explore the levamlodipine different antihypertensive regimens based clinical efficacy of essential hyper-tension.Methods 139 patients, 70 cases of combined acid L-amlodipine and telmisartan; 69 cases of the control group alone Lev-amlodipine acid treatment; acid levamlodipine 2.5 mg, telmisartan 40 mg, 1 times/d, 1 week after treatment failed to achieve target blood pressure, then the acid levamlodipine to 5 mg, telmisartan increased to 80 mg.Result After 6 weeks of combined treatment group total effective rate was 92.9% in the control group was 87.0%, and the two blood pressure significantly lower than before treatment, the difference was statistically significant （P〈0.05）.Conclusion Combined acid L-amlodipine and telmisartan treatment of essentialhypertension improve the efficacy and safety.