维生素E辛烯基琥珀酸酯的合成工艺优化

Optimization of synthesis of vitamin E octenylsuccinate

以4-二甲氨基吡啶(DMAP)和锌粉(Zn)为催化剂,维生素E(V E)和辛烯基琥珀酸酐(OSA)经合成得到维生素E辛烯基琥珀酸酯(V E-OS酯)。通过考察各反应因素对合成工艺的影响,在进行单因素实验的基础上,利用响应面法优化V E-OS酯的合成工艺,建立了拟合良好的数学模型。结果表明,DMAP用量对合成工艺影响最显著;拟合得到的最优合成工艺为OSA与V E的摩尔比为2.3∶1,DMAP与V E的摩尔比为0.2∶1,乙酸乙酯用量61.67mL。拟合得V E理论转化率为100%,验证实验得到V E实际转化率为99.04%,说明响应面法优化有效。

Catalyzed by 4-dimethylaminopyridine（DMAP） and zinc powder（Zn）,vitamin E octenylsuccinate（VE-OS ester） was synthesized by the reaction of octenylsuccinic anhydride（OSA） and vitamin E（VE）. Each reaction factor of synthesis process was studied,and the synthesis of VE-OS ester was optimized by response surface methodology on the base of the single factor experiment,and a well-fitted mathematical model was established. Results showed that the amount of DMAP was the most significant factor for the reaction. The maximum theoretical VE conversion rate of 100% was obtained when the mole ratio of OSA to VE and DMAP to VE were 2.3 ∶1 and 0.2 ∶1,respectively,and the amount of solvent was 61.67mL. The real conversion rate was 99.04% according to the theoretical experimental condition（100%）,indicating that the optimization of synthesis by response surface methodology was effective.