摘要
以4-二甲氨基吡啶(DMAP)和锌粉(Zn)为催化剂,维生素E(V E)和辛烯基琥珀酸酐(OSA)经合成得到维生素E辛烯基琥珀酸酯(V E-OS酯)。通过考察各反应因素对合成工艺的影响,在进行单因素实验的基础上,利用响应面法优化V E-OS酯的合成工艺,建立了拟合良好的数学模型。结果表明,DMAP用量对合成工艺影响最显著;拟合得到的最优合成工艺为OSA与V E的摩尔比为2.3∶1,DMAP与V E的摩尔比为0.2∶1,乙酸乙酯用量61.67mL。拟合得V E理论转化率为100%,验证实验得到V E实际转化率为99.04%,说明响应面法优化有效。
Catalyzed by 4-dimethylaminopyridine(DMAP) and zinc powder(Zn),vitamin E octenylsuccinate(VE-OS ester) was synthesized by the reaction of octenylsuccinic anhydride(OSA) and vitamin E(VE). Each reaction factor of synthesis process was studied,and the synthesis of VE-OS ester was optimized by response surface methodology on the base of the single factor experiment,and a well-fitted mathematical model was established. Results showed that the amount of DMAP was the most significant factor for the reaction. The maximum theoretical VE conversion rate of 100% was obtained when the mole ratio of OSA to VE and DMAP to VE were 2.3 ∶1 and 0.2 ∶1,respectively,and the amount of solvent was 61.67mL. The real conversion rate was 99.04% according to the theoretical experimental condition(100%),indicating that the optimization of synthesis by response surface methodology was effective.
出处
《食品工业科技》
CAS
CSCD
北大核心
2014年第2期246-250,共5页
Science and Technology of Food Industry
基金
浙江省青年自然科学基金(LQ12B06001)
宁波市自然科学基金(2013A610084)
国家级大学生创新创业训练计划项目(201311058011)
浙江省大学生科技创新团队资助项目
宁波市创新团队(2011B82002)
关键词
维生素E辛烯基琥珀酸酯
4-二甲氨基吡啶
响应面法
转化
vitamin E octenylsuccinate(VE-OS ester)
4-dimethylaminopyridine(DMAP)
response surface methodology
conversion