他汀类药物与肾脏

Statin administration and kidney diseases

他汀类药物是心血管疾病(CVD)防治的基石。研究表明,他汀类药物通过纠正血脂代谢紊乱及其多效性机制,可降低肾脏疾病患者发生缺血性心血管疾病和缺血性中风等危险。此外,还有可能通过改变肾脏血流动力学或抑制炎症反应等作用,改善肾功能或延缓肾功能的恶化。但是,也有研究报道他汀类药物对肾脏可能有损害作用。因此,需要进一步认识他汀类药物在肾脏疾病中应用的安全性,客观评估其对肾脏损害的可能性。

Statins have served as the cornerstone for cardiovascular disease （CVD） prevention. Some studies have shown that statins can reduce the risks of ischemic cardiovascular disease and ischemic stroke in patients with chronic kidney disease（CKD） by correcting dyslipidemia and its pleiotropic mechanism. In addition,there may be some changes in renal hemodynamics or the inhibition to the inflammatory response and so on, by which statins improve renal function or delay the deterioration of renal function. However, there were studies showing damage effects on the kidneys. So,there are needs for further understanding of statins in renal disease application and security to get objective assessment of their likelihood of damage to the kidneys.