摘要
目的评价碘对比剂造影术前应用大剂量他汀是否可以预防对比剂肾病。方法检索MEDLINE、EMBASE数据库、中国知网、Corchrane图书馆及二次资源。检索词:对比剂、对比剂肾病、他汀。入选试验满足条件:试验为随机对照试验,试验对象为需要行造影的人群。采用比值比(odds ratio,OR)和95%可信区间(95%confidence interval,CI)作为评价大剂量他汀组和小剂量他汀或安慰剂组对比剂肾病发生率有无差异的指标,用均数差(mean difference,MD)和95%CI作为评价术后血肌酐(SCr)水平有无差异的指标。统计学分析应用RevMan5.0软件。结果在检索到的文章中共有12个实验满足条件,总计2 774例患者。造影术前应用大剂量他汀可减少对比剂肾病发生率(OR=0.44;95%CI=0.34~0.59,P<0.01),并较小剂量他汀或安慰剂组术后SCr水平下降(MD=-0.07;95%CI=-0.10^-0.04,P<0.01)。结论造影术前应用大剂量他汀减少对比剂肾病的发生。
Objective We undertook a meta-analysis of trials to evaluate the impact of high-dose pre-operative statin therapy on the incidence of contrast-induced nephropathy（CIN） in patients undergoing angiography. Methods We searched MEDLINE, EMBASE databases, Cochrane Library, CNKI for articles evaluating the effect of high-dose statins on the incidence of CIN in patients undergoing angiography. The statistical method was processed in RevMan 5.0. Results In the search, randomized controlled trials met the conditions, involving 2 774 patients. High-dose pre- operative statin therapy reduced the incidence of CIN compared to controls （ OR=0. 44;95 %CI --0. 34-0.59, P 〈0.01）. Conclusion High-dose pre-operative statin therapy may reduce incidence of CIN in patients undergoing angiography.
出处
《临床荟萃》
CAS
2014年第1期5-9,共5页
Clinical Focus
