血清同型半胱氨酸与脂蛋白a在高血压临床应用的相关性研究

Correlation analysis of homocysteine and lipoprotein-a in serum in clinical application of hypertension

目的探讨人血清同型半胱氨酸(Hcy)与脂蛋白a[Lp(a)]在高血压临床应用的相关性。方法测定50例健康体检组和261例高血压患者血清中Hcy和Lp(a)水平,进行统计学分析。结果 2组Hcy、Lp(a)比较,差异有显著性。Hcy和Lp(a)不存在相关性(P<0.05)。Hcy和Lp(a)分别检测的阳性率为48.9%和51.4%,两者联合检测的阳性率为60.8%,显著高于单个指标的阳性率(P<0.05)。结论 HCY和Lpa异常代谢均与高血压有关,两者联合测定,可提高对高血压诊断的阳性率,有助于临床对疾病的诊断和判断预后,但两种指标对疾病的诊断没有相关性。

Objective To investigate the correlation of homocysteine （ homocysteine, Hcy） and lipoprotein （ lipoprotein-a, Lpa ） in serum in clinical application of hypertension. Methods HCY and Lpa in the serum of 50 cases of healthy people and 261 patients with hypertension were determined, and statistical analysis was conducted. Results There was significant difference between the hypertension group and the healthy control group. No correlation existed between HCY and Lpa（ P 〈 0.05 ）. The positive rates were 48.9% and 51.4% respectively in the HCY and Lpa tests in the serum of 261 cases. The positive rate of combined detection was 60.8% , significantly higher than the positive rate of the single index （ P 〈 0.05 ）. Conclusion Abnormal metabolism of HCY and Lpa are associated with hypertension. Combined determination can improve the diagnosis of hypertension,which is helpful for clinical diagnosis and prognosis,but two indicators to the diagnosis of diseases have no correla tion.