米非司酮配伍米索前列醇终止16-24周妊娠的临床观察

Clinical observation on termination of 16- 24 weeks' gestation with mifepristone and misoprostol

目的探讨米非司酮配伍米索前列醇终止16～24周妊娠的效果及优越性。方法将2009年1月-2012年12月本院孕16—24周要求终止妊娠的健康妇女随机分为2组，每组各49例。A组予米非司酮150mg口服，阴道后穹隆置入米索前列醇2片；B组予依沙吖啶100mg羊膜腔注射。结果米非司酮配伍米索前列醇在引发规律宫缩至分娩时间，产时产后阴道出血量，胎盘胎膜残留情况及宫颈管成熟情况方面均优于依沙吖啶，差异有统计学意义（P〈0．05），终止妊娠的成功率2组间差异无显著性（P〉0．05）。结论米非司酮配伍米索前列醇终止16～24周妊娠效果优于依沙吖啶羊膜腔内引产，是一种安全、有效、经济、可靠、痛苦小的引产方法，值得临床推广。

Objective To investigate the effect of mifepristone combined with misoprostol in termination of pregnancy of 16 - 24 weeks and its advantage. Methods Healthy women with 16 -24 weeks＇gestation from January 2009 to December 2012 in our hospital who requested termination of pregnancy were randomly divided into two groups, 49 cases in each group. Group A was given mifepristone combined with misoprosto], mifepristone 150 mg oral, vagina] misoprostol tablets of 2. Group B was treated with ethacridine amniotic cavity injection of 100 rag. Results Mifepristone combined with misoprostol was better than ethacridine in terms of triggering regular uterine contraction to delivery time, postpartum hemorrhage, placenta and fetal membranes residue and cervical maturity. The difference was statistically significant （ P 〈 0.05 ） , but the termination of pregnancy success rate had no difference between the two groups ,which was not statistically significant （ P 〉 0.05 ）. Conclusion Mifepristone combined with misoprostol for termination of 16 to 24 week＇pregnancy is superior to ethacridine amniotic cavity induction. It is a safe, effective, economical and reliable method for induced labor, and worth to be clinically promoted.