研制高效疟疾疫苗的几个关键技术问题

Key technological issues in developing effective malaria vaccines

疟疾在很多国家仍然是严重的公共卫生问题，有效的疟疾疫苗将是控制乃至在全球消除疟疾的有效手段之一。抗原的免疫原性、变异性和质量是影响疟疾疫苗成功研制的关键因素，而建立有效的疟疾疫苗功能检测方法是发掘具有潜力的候选抗原的基础。该文综述了这几方面工作的研究结果。

Malaria remains a serious public health problem in many countries. An effective malaria vaccine will be one of the powerful tools to control or even eliminate the disease in the world. Several factors, such as immunogenicity, variation and quality of malaria antigens, are significant influences on the development of successful malaria vaccines. Besides, it is essential and imperative to establish efficient functional assays of malaria vaccines for the discovery of those antigen candidates with the most potential. The efforts made in these aspects are covered in this article.