人型支原体合并解脲脲原体感染的检出率和耐药性分析

Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticumcoinfection

目的了解泌尿生殖道人型支原体(Mycoplasma hominis,Mh)单纯及合并解脲脲原体(Ureaplasma urealyticum,Uu)的感染和耐药情况。方法用选择性固体培养基-液体培养基一步法检测7 486例生殖泌尿道标本中Mh的检出率和耐药情况。结果 Mh单纯检出率为2.8%,合并Uu检出率为11.3%,女性检出率高于男性(P<0.05)。Mh和Mh合并Uu对多西环素和米诺环素的敏感率最高,均>90.0%,对红霉素、罗红霉素、阿奇霉素和克拉霉素耐药率最高,耐药率均大于90.0%。两者对这6种抗生素的敏感率和耐药率差异无统计学意义(P>0.05)。Mh对交沙霉素的敏感率(87.6%)高于混合感染者(75.4%),差异有统计学意义(P<0.05)。结论 Mh单纯感染或混合感染检出率较低,且以女性感染为主,两者的耐药谱基本一致,对半合成四环素的敏感率最高,对大环内酯类抗生素耐药率最高。

Objective To compare the prevalence and antibiotic susceptibility of Mycoplasma hominis （Mh） monoinfection and coinfection with Ureaplasrna urealytiurn （Uu）. Methods A total of 7 486 samples were collected from urogenital tract and cul-tured in the liquid culture medium and selective solid culture medium concomitantly. The prevalence and antibiotic susceptibility were compared and analyzed. Results The prevalence of Mh monoinfection and Mh ＋ Uu coinfection was 2.8 % and 11.3%, respectively. The prevalence was significantly higher in female patients than in male patients （P〈0.05）. More than 90.0% of the isolates from either Mh monoinfection or Mh ＋ Uu coinfection were sensitive to doxycycline and minocycline. However, more than 90.0% of the isolates were resistant to erythromycin, roxithromycin, azithromycin or clarithromycin. No significant difference was found between Mh and Mh ＋ Uu in the in vitro susceptibility to the six antibiotics （P〉0.05）. The susceptibility to josamycin was significantly different between Mh and Mh ＋ Uu （87.60% vs. 75.4%, P〈0.05）. Conclusions The prevalence of Mh and Mh ＋ Uu is tow in genitourinary tract infections. Mh and Mh ＋ Uu infections are mainly found in females. Both Mh and Mh ＋ Uu show similar antibiotic resistant pattern, which indicates good susceptibility to semisynthetic tetracyclines and high resistance to macrolides.