人乳头瘤病毒检测在宫颈CIN诊断及随访中的意义

Significance of Detection of Human Papillomavirus(HPV)in Cervical CIN Diagnosis and Follow-up

目的:研究HPV检测在宫颈上皮内瘤变(CIN)诊断及术后随访中的价值。方法:选取宫颈上皮内瘤变患者120例、宫颈炎患者140例纳入研究,检测HPV阳性情况及术后随访情况。结果:宫颈炎组患者中HPV阳性38例(27.14%),CINⅠ组HPV阳性率为76.32%(29/38),CINⅡ组为82.50%(33/40),CINⅢ为92.86%(39/42),随着宫颈病变程度的加重,HPV阳性率逐渐增大,比较差异有统计学意义(字2=86.710,P<0.05)。120例CIN患者中,术后6个月HPV阳性率为22.50%(27/120),术后1年HPV阳性率为7.50%(9/120),均明显低于手术前84.17%(101/120)(字2=91.674、142.053,P<0.05)。术后1年复查,9例HPV阳性者中,5例(55.57%)出现CIN病变,111例HPV阴性者中,5例(4.50%)出现CIN病变(字2=28.403,P<0.05)。结论:HPV检测有助于鉴别宫颈上皮内瘤变患者与宫颈炎、判断CIN预后,具有积极的临床价值。

Objective：To study the value of HPV testing in diagnosis and postoperative follow-up in cervical intraepithelial neoplasia（CIN）. Method：120 patients with cervical intraepithelial neoplasia,140 patients with cervicitis were selected as research objects,and HPV-positive and postoperative follow-up situation were detected.Result：There were 38 cases（27.14%）with HPV-positive in cervicitis group,76.32%（29/38）with HPV-positive in CINⅠgroup,82.50%（33/40）in CINⅡgroup and 92.86%（39/42）in CINⅢgroup.With the severity of cervical lesions,HPV-positive rate gradually increased,the difference was statistically significant（X2=86.710,P〈0.05）.In 120 patients with CIN,HPV-positive rate was 22.50%（27/120） after treatment for 6 months,and 7.50%（9/120）after 1 year.They were significantly lower than that 84.17%（101/120）before treatment（X2=91.674, 142.053,P〈0.05）.1 year after treatment,there was 5 cases（55.57%）appeared CIN lesions in 9 cases with HPV-positive,5 cases（4.50%）appeared CIN lesions in 111 cases with HPV-negative （ X2=28.403,P〈0.05）.Conclusion：HPV testing can help identify patients with cervical intraepithelial neoplasia and cervicitis,and CIN prognosis.It has a positive clinical value.