巴柳氮(Balsalazide)的合成

Synthesis of Balsalazide

目的 :合成巴柳氮并进行工艺改进。方法 :以对 硝基苯甲酰氯为原料 ,经氨解、氢化、重氮化及偶合四步反应得到了巴柳氮。结果 :所得产物经元素分析、红外光谱确证其结构。结论 :采用此法合成巴柳氮是可行的 。

OBJECTIVE:To synthesize balsalazide and optimize the process.METHODS:This compound was synthesize by steps of ammonolysis,hydrogenize,diazotization and coupling from 4 nitrobenzoyl chloride.RESULTS:Chemical structure of the product was confirmed by element analysis and IR.CONCLUSION:This synthetic method was feasible and the overall yield was raised.