MODS患者外周血中PPARγ与TNF-α变化研究

目的研究多器官功能障碍综合征(MODS)患者外周血中过氧化物酶体增殖物激活受体γ(PPARγ)与肿瘤坏死因子α(TNF-α)动态变化情况。方法以2013年8月-2014年2月收治的22例MODS患者为研究对象,对患者入院1、3、5、7、14 d的PPARγ与TNF-α与同期健康对照组进行比较分析。结果 MODS患者外周血中PPARγ与TNF-α明显高于健康对照组(P<0.05),随着治疗时间的增加,MODS患者外周血中PPARγ从1 d的(106.75±71.87)ng/L降低到与14 d的(40.45±28.82)ng/L TNF-α从1 d的(898.54±3.25)降低到与14 d的(159.52±1.57),均明显下降,差异有统计学意义(P<0.05)。结论考虑PPARγ与TNF-α可能直接参与MODS发生和发展,可作为MODS病情判断重要指标和治疗潜在靶点。

Objective To study dynamic changes of Peroxidase body growth activated receptor gamma（PPARy） and tumor necrosis factor alpha（TNF-α in peripheral blood of patients with the multiple organ dysfunction syndrome （MODS）. Methods 22 patients with MODS in the hospital from August 2013 to February 2014 were treated ,the levels of PPARy and TNF-α when patients admitted to hospital 1,3,5,7, 14 were compared with the healthy control group at the same period. Results PPARy peripheral blood of patients with TNF-α MODS was significantly higher than the healthy control group （P〈0.05）, with the treatment time increased, PPARy and TNF-α in peripheral blood of patients with COPD were significantly decreased, the difference was statistically significant （P〈0.05）.Conclusion Considering the PPARy and TNF-α may be directly and development ofMODS, MODS can be used as an important indicator of the disease and determine the therapeutic potential targets.