格拉司琼联合低剂量地塞米松预防女性腹腔镜术后恶心呕吐临床观察

目的观察格拉司琼联合低剂量地塞米松与单用格拉司琼预防女性腹腔镜术后恶心呕吐的临床效果观察。方法选择择期行腹腔镜下手术女性患者80例。采用Doll′s临床病例随机表将患者分为两组,即GD组、G组。G组于手术结束前静脉滴注格拉司琼3 mg,GD组于诱导时静脉注射地塞米松5 mg,手术结束前静脉滴注格拉司琼3 mg。观察术后24 h内恶心和呕吐的发生情况,并记录采用补救药物情况;采用视觉模拟评分法评价恶心、呕吐的程度。结果 GD组腹腔镜术后恶心呕吐发生率为20%,G组腹腔镜术后恶心呕吐发生率为37.5%,两组之间比较差异有统计学意义(P<0.05)。结论格拉司琼联合低剂量地塞米松可以明显减少女性腹腔镜手术后恶心呕吐的发生,而且比单剂量使用格拉司琼效果更佳。

Objective To observe the clinical effects of granisetron plus low-dose dexamethasone and granisetron alone to prevent Nausea and vomiting of female patients after laparoscopic surgery. Methods 80 cases of female patients after laparoscopic surgery were selected in our hospital. And adopt the clinical Doll＇ scase random form to divide the patients into two groups randomly, that is,GD group and G group. In G group 3 mg of granisetron Intravenous infusion at the end of surgery;In GD group 5 mg of dexamethasone Intravenous infusion at induction firstly, then 3 mg of granisetron at the end of surgery. To observe the occurrence of nausea and vomiting within 24 h after surgery, And record the use of rescue medication; Evaluated the degree of nausea, retching, vomiting with Visual analogue scale.Results The nausea and vomiting rate of GD group after laparoscopic surgery was 20% and the G group was 37.5%. There was a significant difference between the two groups（P〈0.05）. Conclusion Granisetron plus low-dose dexamethasone can significantly reduce the incidence of nausea and vomiting of female patients after laparoscopic surgery, and it is better than granisetron alone.