肺炎链球菌对抗生素耐药性分析

Analysis on Antibiotic Resistance of Streptococcus Pneumoniae

目的评价儿童流行性感冒人群中肺炎链球菌感染及耐药性,为临床提供准确可靠的诊疗依据。方法选择儿科流感伴呼吸道感染患者153例,分别进行痰及咽拭子细菌培养,并进行青霉素G等16种抗生素药物敏感试验,分析流感人群中肺炎链球菌的感染率、耐药率及β-内酰胺酶产生率。结果在153份标本中,检出肺炎链球菌26株,占17%;除了对红霉素、克林霉素、四环素100%耐药,对其他抗生素均有不同程度的耐药,但万古霉素、头孢呋辛、利福平及呋喃妥因具有100%的敏感性;β-内酰胺酶产生率为66%。结论检出的26株肺炎链球菌,对青霉素耐药率为27%,中敏率达到49%,提示存在耐药趋势,β-内酰胺酶产生株全部耐受青霉素G并具多重耐药。

Objective To evaluate the state of Strepto - occus pneumoniae infection in children with influenza, andto provide accurate and reliable basis for clinic. Methods A total of 153 specimens of sputum and throat swabscollected from ill children with respiratory tract infection,which was performed germicuhure and drug susceptibility tests to 16 antibiotics such as penicillin G, the infective rate, drug resistant rate and β - lalilases in - cidence of S. pneumoniae were analysed. Results The identified rate of S. pneumoniae in 153 specimens was 17% （26/153） ;the resistant rate to erythro- mycin, clindamycin and tetracycline was 100% and it was found that these bacteria were also resistant to all the other agents in different degrees except susceptible to vancomycin, cefuroxime sodium, rifampicine and nitrofurantoin;the incidence of β-lactamases was 66%. Conclusions Among the 51 identified S. pneumoniae, the resistant rate to penicillin was 27%, the intermediate susceptibility was 49%, which suggested that drug resistant tendency be in existence ; β- actamases producing strains were all resistant to penicillin G and showed multidrug resistance;using drug according to experiences could not control the disease effectively, however,it would result in drug- resistance.