肝阳上亢证患者心理特征及血浆β-内啡肽水平研究

A Study on the Psychosocial Characteristics and Plasma Endorphin Levels in Patients with Gan Yang Shang Kang Zheng

为探讨肝阳上亢证患者的心理特征和血浆 β 内啡肽 (β EP)水平 ,采用生活事件量表、社会支持评定量表、应对方式问卷、Beck焦虑量表和Beck抑郁问卷对肝阳上亢证及相关证进行测量 ,并同步检测血浆 β EP。结果 :肝阳上亢证和肝火上炎证患者负性事件数、负性刺激量、焦虑积分及血浆 β EP测值均显著高于健康人与肝肾阴虚证组 ;肝阳上亢证组抑郁积分显著低于肝肾阴虚证组 (P <0 .0 5 )。肝阳上亢证组血浆 β EP测值与负性事件数、负性刺激量、焦虑积分 ;焦虑积分与负性事件数、负性刺激量、消极应对分均呈显著正相关。结论 :肝阳上亢证患者心理应激水平增高 ,表现为以焦虑为主的情绪障碍 ,并伴有血浆 β EP水平增高。

To explore psychosocial characteristics and levels of plasma β EP in patients with Gan Yang Shang Kang Zheng(GYSKZ), patients of GYSKZ and relevant Zheng were investigated with life event scale ,social support rating scale,coping style questionnaire, Beck anxiety inventory and Beck depression inventory.The plasma β EP contents of all subjects were determined simultaneously.Results:Compared with healthy subjects and Gan Shen Yin Xu Zheng (GSYXZ)patients,GYSKZ and Gan Huo Shang Yan Zheng (GHSYZ) patients experienced more frequence of negative life events ,perceived greater impatct of negative life events,and increased anxious score and plasma β EP level.Depressive scores of GYSKZ patients was significantly lower than GSYXZ patients (all P<0.05). Plasma β EP had significant positive correlation with negative life event frequence and stimulus intensity as well as anxious scores. Anxious scores of GYSKZ patients existed a significant positive correlation with negative life event frequence and stimulus intensity as well as scores of negative coping.Conclusion:GYSKZ patients manifested anxious emotional disorder and increased plasma β EP level due to being in state of high level of psychological stress.