转移因子对甲肝疫苗的热稳定性及免疫佐剂作用

The Function of Tranfer Factor to the Stability and Adjuvant of Attenuated Live Vaccine of HAV

转移因子 (TF)具有增强甲肝疫苗热稳定性的作用 ,其效果与 1M的MgCl2 相当 ,加入TF的甲肝疫苗在 4～ 8℃保存 6个月、室温保存 2 1天、37℃保存 7天 ,滴度基本不变 ,仍在6 5LgCCID50 /ml的合格范围内。当提高保存温度时 ,这种作用效果更明显 ;另外 ,TF还具有一定的免疫佐剂作用 ,甲肝疫苗与TF混合后免疫小白鼠 ,阳转率 (10 / 10 )比对照组 (8/ 10 )高 ,几何平均滴度是对照组的 1 6

The study is about the transfer factor (TF) being capable of enhancing the stability of attenuated live vaccine of HAV with the effect as same as 1M MgCl\-2.The titer of vaccine mixed with TF still was higher than 6.50 log CCID/ml after being stored at 4～8 ℃ for 6 months,room temperature for 3 weeks.37℃for 7 days.The result showed that the HAV antibody rates of the mice immunized by live attenuated Hepatitis A vaccine with or without TF were 100% and 80% after injected for 5 weeks, and the GMT were 1∶1.62 and 1∶2.64. It showed good immunoresponse when live attenuated hepatitis A vaccine mix with TF.