激素序贯疗法治疗活动期类风湿关节炎的近期疗效分析

Recent Analysis of the Efficacy of Sequential Therapy of Hormone Active Rheumatoid Arthritis

目的探讨激素序贯疗法治疗活动期类风湿关节炎的近期疗效。方法将我院就诊的84例活动期类风湿关节炎患者随机分为两组,均给予甲氨蝶呤片和柳氮磺胺吡啶片口服,在此基础上,对照组加用泼尼松片口服治疗,观察组采用激素序贯疗法。结果观察组患者的晨僵情况、疼痛和肿胀缓解时间均优于对照组(P<0.05),治疗1周后观察组的ESR、CRP水平下降较明显(P<0.05);治疗1个月后(近期)两组患者观察指标水平相当(P>0.05)。结论激素序贯疗法治疗活动期类风湿关节炎能迅速缓解症状,早期疗效显著,近期疗效相当。

Objective To investigate the efficacy of sequential therapy of hormone in treating active rheumatoid arthritis（RA）. Method 84 patients with active rheumatoid arthritis in our hospital divided into two groups, they were given methotrexate and sulfasalazine, on this basis, the control group was added prednisone, the observation group was added sequential therapy of hormone. Results Morning stiffness, tl^e remission time of pain and swelling in the observation group were better than the control group （P〈0.05）, ESR and CRP dropped significantly after a week of treatment in.the observation group （P〈0.05）; the outcome measures were alike in the two groups （P〉0.05）. Conclusion The active rheumatoid arthritis treated with sequential therapy of hormone can relieve symptoms quickly, the curative effect is remarkable in the early-term and similar in the short-term.