B型利钠肽与心肾综合征相关性的临床研究

Clinical Study of B Type Natriuretic Peptide and Cardiac and Renal Syndrome Correlation

目的探讨B型利钠肽与心肾综合征的临床相关性。方法选取我院近年来收治的心力衰竭患者226例，将患者根据有无合并肾功能损害将其分为两组，单纯心力衰竭组113例，心肾综合征组103例。观察记录患者的心力衰竭症状以及各项体征指标，对患者的血肌酐和血尿素氮水平进行化验。对患者的B型利钠肽和氨基末端B型利钠肽前体进行检验分析。结果心肾综合征组的113例患者的BNP、NT-proBNP显著高于单纯心力衰竭组患者，比较差异具有统计学意义（P〈0．05）；心肾综合征组患者以24.3％的病死率显著高于单纯心力衰竭组患者，比较差异具有统计学意义（P〈0．05）；心肾综合征组患者的死亡时间为1～30d，平均死亡时间为5d，单纯心力衰竭组患者的死亡时间为3～12d，平均死亡时间为7d，两组患者的死亡时间比较差异具有统计学意义（P〈0．05）。结论心肾综合征患者血液的BNP、NT-proBNP的浓度明显的高于单纯的心力衰竭患者，表明了B型利钠肽的失代偿在患者发生心肾综合征中具有重要的作用。

Objective To investigate the clinical relevance of B type natriuretic peptide and heart and kidney syndrome. Methods In our hospital in recent years treated 226 patients with heart failure, the patients according to whether the patients have impaired renal function will be divided into two groups, with 113 cases of heart failure group, heart and kidney syndrome in 103 cases. Observe and record the symptoms of heart failure patients and all kinds of signs, laboratory tests on blood creatinine and blood urea nitrogen levels in patients with. The B type natriuretic peptide and N-terminal B type natriuretic peptide in patients with precursor test analysis. Results 113 cases of patients with BNP, NT-proBNP cardiorenal syndrome group was significantly higher than that of pure in heart failure patients, compared the difference was statistically significant （P〈0.05）; cardiorenal syndrome patients with a 24.3 % mortality rate was significantly higher than that of pure heart failure group, compared the differences were statistically significant （P〈0.05）; cardiorenal syndrome patients time of death was 1-30 days, mean time to death was 5 days, the time of death in patients with heart failure group were 3-12 days, mean time to death was 7 days, the time of death of patients in the two groups there were significant differences （P〈0.05）. Conclusion The pure heart failure patients is higher than the concentration of cardiorenal syndrome in patients with blood BNP, NT-proBNP obviously, show that the B type natriuretic peptide in patients with decompensated heart kidney synthesis plays an important role in.