摘要
目的:开发夫西地酸凝胶剂并研究其体外渗透。方法:加热搅拌法制备夫西地酸凝胶剂,高效液相色谱法测定其主药含量,透皮扩散考察体外释放特性。结果:凝胶剂中夫西地酸为标示含量的96.70%(RSD=0.42%),体外释放方程lnQ=0.3833lnt-0.8241(r2=0.9996)。结论:夫西地酸凝胶药物含量均匀,质量控制方法可靠,体外释放符合Ritger-Peppas方程。
Objective： To develop the new gel formulation of fusidic acid and explore its in vitro transdermal permeation. Methods： The gel was prepared by heatingagitating,and the content of fusidic acid was determined by high efficiency liquid chromatography,the in vitro release characteristics was researched by transdermal diffusing. Results： The relative content of fusidic acid was 96.70%（RSD = 0.42%）,the in vitro release equation was lnQ=0.3833lnt-0.8241（r2=0.9996）. Conclusion： The contents of the preparation are uniform,the method of quality control is reliable,the in vitro release characteristics accords with the Ritger-Peppas equation.
出处
《药学与临床研究》
2013年第6期622-624,共3页
Pharmaceutical and Clinical Research
