金乌骨痛胶囊联合阿法骨化醇治疗膝骨关节炎合并骨质疏松症的临床疗效观察

Clinical observation on treating knee osteoarthritis combined with osteoporosis with Jinwu Gutong capsule plus alfacalcidol

目的：观察和评价金乌骨通胶囊联合阿法骨化醇对于膝骨关节炎合并骨质疏松症患者的，陆床疗效。方法：入纽60例经临床X线、骨密度和临床病史确诊的患者，随机分成两组，治疗组口服金乌骨通胶囊＋法能，对照组口服荚太青＋法能，治疗8周后，通过WOMAC的评分进行疗效评估，同时测定25—OH-VD3和骨转换指标（骨钙素OC、1^-型原胶原N-端前肽PINP和血清I型胶原交联C-末端肽S-CTX），了解对骨代谢改善情况。结果：治疗8周后，两组的膝关节疼痛均有减轻（P〈0．01），日常活动的难度明显降低（P〈0．01），膝关节晨僵及僵硬度有减轻（P〈0．05）。两组间比较，治疗组均更胜一筹（P〈0．05～0．01）。血清中25-OH-VD3恢复到正常51．5nmo／L以上，治疗组中血清骨钙素较治疗前和对照组均有升高（P〈0．05）。结论：金乌骨通胶囊联合阿法骨化醇对膝骨关节炎合并骨质疏松症患者的治疗，可以达到缓解疼痛，提高膝关节及肢体的活动度，同时改善生活质量，能长期应用，同时亦能增加骨钙素，提高骨骼成骨功能，纠正骨代谢的失衡。

Objective： To observe and evaluate clinical efficacy of Jinwu Gutong capsule plus alfacalcidol for treating knee osteoarthritis combined with osteoporosis. Methods： 60 cases enrolled by clinical X-ray, bone density and clinical history of patients diagnosed were randomly divided into two groups, the treated group was treated with Jinwu Gutong capsule combined with alfacalcidol, control group oral Yingtaiqing with alfacalcidol. After eight weeks of treatment, to evaluate efficacy by WOMAC score, the simultaneous determination of 25-OH-VD3 and bone turnover markers （osteocalcin, OC, I procollagen N-terminal propeptide of type I collagen and serum PINP crosslinked C- terminal peptide S-CTX）, to understand the bone metabolism improving situation. Results： After eight weeks, knee pain reduced in the two groups （P〈0.01）, the difficulty of daily activities significantly reduced （P〈0.01）, morning stiffness and stiffness degree in the knee decreased （P〈0.05）. Between the two groups, the treated group were superior （P〈0.05-0.01）. Serum 25-OH-VD3 to normal 51.5nmol/L or more, serum osteocalcin of the treated group compared to pre-treatment control groups were increased （P〈0.05）. Conclusion： Jinwu Gutong capsule plug alfacalcidol can achieve pain relief, improve the knee joint and limb mobility and improve the quality of life. Worthy of long-term applications, while also increased osteocalcin and improve bone osteoblast function, to correct an imbalance in bone metabolism.