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Runx2及其在骨组织工程中的应用 被引量：6

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摘要 Runx2在成骨分化信号转导通路中起核心作用,能够诱导骨髓间充质干细胞(BMSC)向成骨细胞定向分化并促进成骨细胞和软骨细胞成熟,从而促进骨愈合,被视为骨组织工程中最具有应用前景的转录因子之一。利用携带Runx2基因的腺病毒载体感染BMSC,使BMSC中Runx2蛋白表达增高,并将BMSC复合于骨材料上以提高骨性愈合效率,已成为骨组织工程研究新热点。该文就Runx2及其在骨组织工程中应用研究进展作一综述。
作者 李庆庆 黄江鸿 何美健 赵忠玮 王大平
机构地区 汕头大学医学院深圳二院临床学院
出处 《国际骨科学杂志》 2014年第1期44-46,共3页 International Journal of Orthopaedics
基金 广东省自然科学基金(S2012010008129)
关键词 RUNX2 成骨分化 组织工程 再生医学
分类号 R318 [医药卫生—生物医学工程]
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参考文献29

  • 1Liu TM, Lee EH. Transcriptional regulatory cascades in Runx2-dependent bone development[J]. Tissue Eng Part B Rev, 2013, 19(3) :254-263.
  • 2Chuang LS, Ito K, Ito Y. RUNX family: Regulation and diversification of roles through interacting protdns[J]. Int J Cancer, 2013, 132(6):1260-1271.
  • 3Galindo M, Pratap J, Young DW, et al. "Pne bone-specific expression of Runx2 oscillates during the cell cycle to support a Gl-related antiproliferative function in osteoblasts[J]. J Biol Chem, 2005, 2:80(21):20274-20285.
  • 4Cohen MM Jr. tdiology of RUNX2 and cleidocranial dysplasia[J]. J Craniofac Surg, 2013, 24(1):130-133.
  • 5Li YL, INi ZJ, Zheng SP, et al. Individual function difference of Runx2 isoforms in bone formation by RNA inferen[J]. Cell Biol Int, :2008, 32(3) :S22.
  • 6INlle-Carhonare L, Innamorati G, Valenti MT. Transcription factor Runx2 and its application to hone tissue exNineering[J]. Stem Cell Rev, 2012, 8(3) :891-897.
  • 7Khatiwala CB, Kim PD, Peyton SIR, et al. ECM compliance regulates osteogenesis by influendng MAPK signaling downstream of RhoA and RC/2K [J]. J Bone IVfiner Res, 2009, 24(5):886-898.
  • 8Kanno T, Takahashi T, Tsujisawa T, et al. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts[J]. J Cell Biochem, 2007, 101(5) :1266-1277.
  • 9Chen G, Deng C, Li YP, et al. TGF-β and BMP signaling in osteoblast differentiation and bone formation[J]. Int J Piol Sci, 2012, 8(2) :272-288.
  • 10Jensen ED, Schroeder TM, Bailey J, et al. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation- independent rnarmer[J]. J Bone Miner Res, 2008, 23(3):361-372.

同被引文献75

  • 1王跃春,张洹,谭广销.人胎肾间充质样干细胞分离鉴定及其向脂肪和成骨细胞的分化[J].中国临床康复,2006,10(25):17-20. 被引量：2
  • 2孙强,邱勇.转录因子Runx2、Osterix与骨髓间质干细胞的成骨分化[J].江苏医药,2006,32(7):657-659. 被引量：6
  • 3Mrosek EH, Schagemann JC, Chung HW, et al. Porous tantalum and poly-epsilon-caprolactone biocomposites for osteochondral defect repair: preliminary studies in rabbits. J Orthop Res, 2010, 28(2): 141-148.
  • 4Fernandez-Fairen M, Querales V, Jakowlew A, et al. Tantalum is a good bone graft substitute in tibial tubercle advancement. Clin Orthop Relat Res, 2010, 468(5): 1284-1295.
  • 5Wang N, Li H, Wang J, et al. Study on the anticorrosion, biocompatibility, and osteoin-ductivity of tantalum decorated with tantalum oxide nanotube array films. ACS Appl Mater Interfaces, 2012, 4(9): 4516-4523.
  • 6中华人民共和国国家标准. GB/TISO10993-5: 2009 医疗器械生物学评价. 北京: 中国标准出版社, 2009.
  • 7Sagomonyants KB, Hakim-Zargar M, Jhaveri A, et al. Porous tantalum stimulates the proliferation and osteogenesis of osteoblasts from elderly female patients. J Orthop Res, 2011, 29(4): 609-616.
  • 8Fox P, Pogson S, Sutcliffe CJ, et al. Interface interactions between porous titanium/tantalum coatings, produced by Selective Laser Melting (SLM), on a cobalt-chromium alloy. Surface Coatings Techonlogy, 2008, 202(20): 5001-5007.
  • 9Hoang QQ, Sicheri F, Howard AJ, et al. Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature, 2003, 425(6961): 977-980.
  • 10Liu TM,Lee EH.TranscriptionalregulatorycascadesinRunx2-dependentbonedevelopment[J].Tissue Eng Part BRev,2013,19(3):254-263.

引证文献6

二级引证文献19

国际骨科学杂志
2014年 第1期

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