经皮冠状动脉介入术围手术期抗栓药的利用

Antithrombotics utilization for perioperative of percutaneous coronary intervention

目的了解经皮冠状动脉介入术(PCI)围手术期抗栓药的处方习惯。方法前瞻性研究,共纳入2011至2012年137名患者。临床药师记录患者的人口学特征、疾病和用药情况,评估医生遵循指南程度、患者对抗栓药的了解和依从性。结果最常用的抗栓药物为氯吡格雷和阿司匹林,出院带药率分别为96.3%,77.6%。94.9%患者的氯吡格雷负荷量为300 mg,71.5%的维持量为75mg·d-1;134例用了双联抗血小板治疗。临床药师对118例患者进行了用药教育,仅2.5%患者了解药物的主要信息。结论临床医生抗栓药物的处方基本遵循指南。药学监护有助于临床合理用药。

Objective To evaluate the prescribing patterns of antithrom- botic agents for perioperative of pereutaneous coronary intervention and conduct the pharmaceutical care for patients. Methods A prospective study, clinical pharmacists recorded the demographic variables, diagnosis of diseases and drug prescribing; assessed physician＇s compliance with the guidelines; scored the knowledge and adherence to antithrombotics. Results A total of 137 patients were enrolled in the study during 2011.9 -2012. 11, among which 105 were men and 32 were women. Aspirin and clopidogrel were among the most commonly prescribed a- gents, 96.3% and 77.6% of patients discharged with clopidogrel and aspirin respectively,94.9% of clopidogrel＇ s loading dose was 300 mg, 71.5% of maintenance dose was 75 mg ~ d-~. The total of 134 patients received dual antithrombotic therapy. Clinical pharmacists provided edu- cation for 118 patients, only 2.5% of patients knew all information of drugs. Conclusion Physicians can compliant with the guidelines. Phar- maceutical care has primary role in rational drug use.