齐拉西酮临床研究进展

Proress in clinical research of ziprasidone

齐拉西酮是一种新型的非典型抗精神病药,其血浆药物水平稳定,疗效明显优于安慰剂。注射用齐拉西酮为需要快速控制激越症状的患者提供了较好的治疗方案。齐拉西酮不良反应较少,耐受性佳,可改善患者生活质量和社会功能,可作为第一线抗精神病药物单一使用。本文对其药理学、药代动力学及临床应用研究等进展进行了综述。

Ziprasidone （ZIP） is a new kind of atypical antipsychotic drugs which keeps stable in plasma. Its curative effect is better than pla- cebo. ZIP for injection provides a better treatment mode for the patients who need control agitation rapidly. ZIP has less adverse effects and well tolerated, which can improve quality of life and social function of the pa- tients. ZIP can be used as the first -line antipsychotics singly. This arti- cle reviewed the pharmacology, pharmacokinetics and clinical research of the related literature about ziprasidone, providing references for its clini- cal application.