地龙低温超微粉碎特性考察

Characteristics Investigation of Low Temperature Pulverization of Pheretima

目的：考察地龙低温超微粉碎的工艺参数及粉体学性质。方法：采用高速中药粉碎机将地龙粉碎至均匀粒度，利用振动式低温超微粉碎机对地龙粉末进行再次粉碎，每3min取样，直至25min全部取出，检测样品粒径、比表面积及孔隙率。结果：随粉碎时间的增加，粒径先逐渐减小，而后粒子开始团聚使粒径增加；比表面积及孔隙率随粉碎时间先增加后减小。吸附一脱附曲线显示发生凝聚和蒸发时相对压力集中分布于0．8—1．0；粉碎9min样品中N2吸附量最大，且与其余样品存在明显差异。结论：振动式超微粉碎可将地龙粉碎至微米级，低温粉碎可保证地龙有效成分不发生变化，且达适宜粉碎粒径后不容易聚集，符合小金丸粒子设计对地龙的要求。

Objective： To investigate process parameters and powder characteristics of Pheretima after low temperature pulverization. Method： Pheretima was crushed again by vibration type low temperature ultrafine pulverizer after it was crushed to uniform particle size with high speed grinderof Chinese medicine, sampling every 3 min until all samples out of machine by 25 min, then particle size, specific surface area and porosity of samples were tested. Result： With increasing of grinding time, particle size decreased gradually, then particle size increased after agglomeration of particles; specific surface area and porosity increased firstly and then decreased. Adsorption-desorption curve showed that relative pressure concentrated in 0.8-1.0 when condensation and evaporation occurred; Adsorption quantity of N2 in sample was maximum after crushed 9 min, and it had significant differences with other samples. Conclusion： Pheretima could be crushed to micron level by vibration type low temperaturepulverization, low temperature pulverizationcould guarantee active ingredients in Pheretima unchanged, and it was not easy to gather after crushed to appropriate particle size, which reached particle design requirements of Pheretima in Xiaojin pills.