凯时联合托拉塞米治疗高血压性慢性肾功能衰竭疗效观察

Effects of kaishi injection combined with torasemide in the treatment of hypertensive chronic renal failure

目的观察凯时注射液联合托拉塞米对高血压引起的慢性肾功能衰竭的疗效。方法选择在该科住院由高血压引起的慢性肾功能衰竭患者66例,随机分为观察组(凯时联合托拉塞米组)和对照组(单用凯时组),每组33例。两组在常规治疗基础上,治疗组给予凯时注射液10μg加入0.9%氯化钠注射液10 ml中缓慢静推,托拉塞米注射液20 mg加入0.9%氯化钠注射液10 ml中缓慢静推;对照组给予凯时注射液10μg加入0.9%氯化钠注射液10 ml中缓慢静推,14 d为1个疗程。治疗前后检测24 h尿蛋白定量、血清肌酐(SCr)、血尿素氮(BUN)。结果两组治疗前后SCr、BUN和24 h尿蛋白比较差异均有统计学意义(P<0.01);两组治疗后三项指标均降低(P<0.01),但观察组降幅大于对照组(P<0.01)。结论凯时注射液与托拉塞米联合应用对高血压引起的慢性肾功能衰竭有良好的疗效。联合应用比单用凯时疗效更好。

Objective To investigate the clinical effects of kaishi injection combined with torasemide in the treatment of patients with hypertensive chronic renal failure. Methods Sixty-six patients with hypertensive chronic renal failure were enrolled and randomly divided into observation group and control group, thirty-three cases for each group. Patients in the observation group were treated with kaishi injection combined with torasemide, the patients in the control group were treated with kaishi injection only. After fourteen days＇ treatment, SCr, BUN and 24h urinary protein were measured. Results After treatment the levels of SCr, BUN and 24h urinary protein decreased in two groups, but the reduction of above indexes in the research group was much lower than the control group（ P 〈 0. 01 ）. Conclusion Kaishi injection combined with torasemide has more positive effect in the treatment of hypertensive chronic renal failure than kaishi injection only.