紫杉醇脂质体联合顺铂方案在晚期宫颈癌诱导化疗中的应用

The application of paclitaxel liposome combined with cisplatin regimens as induction chemotherapy in the treatment of advanced cervical cancer

目的评价紫杉醇脂质体联合顺铂方案作为诱导化疗在宫颈癌治疗中的抗肿瘤作用及毒性。方法选择晚期宫颈癌患者73例,按照住院单、双号分为TP方案组(41例)和FP方案组(32例)。TP方案组采用紫杉醇联合铂类药物诱导化疗;FP方案组采用5-氟尿嘧啶联合铂类药物诱导化疗。化疗均为2个疗程,配合后装92Ir放疗,然后评价两组抗肿瘤效果,再进行手术治疗。结果两组治疗总有效率分别为75.6%和46.9%,TP方案组总有效率高于FP方案组(P<0.05)。两组化疗毒副反应强度差异无统计学意义(P均>0.05)。结论紫杉醇脂质体联合顺铂是一种非常有效的诱导化疗方案,有助于控制肿瘤,达到术前治疗的目的。

Objective To evaluate the efficacy and toxicity of paclitaxel liposome combined with cisplatin as induction chemotherapy in the treatment of cervical cancer. Methods Seventy-three patients who received chemo- therapy of paclitaxel liposome combined with cisplatin（TP program） and 5-fluorouracil （FP regimens） were retrospec- tively analyzed. There were 41 patients in TP group and 32 patients in FP group. All patients received induction chemo- therapy combined with the afterloading radiotherapy 15 ~20 Gy for two courses of treatment. Results The efficiency of TP group and FP group were 75.6% and 46.9% respectively, the efficient of TP group was higer than FP group（P 〈 0. 05） ,there was no statistically significant difference in the toxic side effects between two groups（ P all 〉 0.05 ）. Conclusion Chemotherapy of paclitaxel liposome combined with cisplatin is a very effective induction chemotherapy which can controI the progression of tumor and treat the tumor before surgery.