乳头状肾细胞癌8例临床病理分析

Clinical pathological analysis of 8 cases of papillary renal cell carcinoma

目的探讨乳头状肾细胞癌（PRCC）的临床病理特点、诊断及鉴别诊断要点。方法回顾分析8例乳头状肾细胞癌的临床资料、病理学特点及免疫组化表型。结果8例中有2例为女性，年龄在45—63岁之间。5例为右肾，3例为左肾。主要临床表现为腰部疼痛。光镜下PRCC主要由恶性上皮细胞构成的多少不等的小管和乳头状结构。免疫组化：肿瘤细胞PCK（＋），CK7（＋），CK8（＋），EMA（＋），S-100（＋），Vimentin（＋），CD10（-）。结论乳头状肾细胞癌明确诊断需结合病理学特点及免疫表型，且需要与肾脏其他肿瘤进行鉴别。

Objective To explore the clinical and pathological features, differential diagnosis of papil- lary renal cell carcinoma（PRCC）. Methods Retrospectively analyze 8 cases of PRCC for their clinical data, pathological features and immunohistochemistry phenotype. Results 2 of the patients were female whose ages ranged from 45 to 63. Five tumors were located in the right kidney and other three in the left kidney. The major clinical manifestation of the eight PRCC was the waste pain. The tumor histo｜ogic architecture was papillary or tubupapilary, immunohistochemically, CK7, CK8, EMA and Vimentin were positive in the eight cases. CDIO was negative. Conclusion The diagnose of PRCC depends on pathological characteristics and expression of im- munohistochemistry.