消炎痛联合柴胡注射液治疗干扰素所致发热的临床研究

Indomethacin and bupleurum injection in treatment of interferon induced fever

目的对比使用干扰素首剂前给予不同的治疗措施预防干扰素所致的发热,以观察消炎痛联合柴胡注射液对预防干扰素所致发热的临床效果。方法对住院的90例病毒性肝炎患者,随机分为试验组30例、对照a组30例及对照b组30例,在使用干扰素前30min试验组予消炎痛口服及柴胡注射液保留灌肠,对照a组予柴胡注射液保留灌肠,对照b组予消炎痛口服。结果试验组与两对照组降温效果比较有统计学意义(P<0.05);对照a组与对照b组降温效果经统计学处理无差异(P>0.05)。结论使用干扰素前予消炎痛口服联合柴胡注射液保留灌肠,对预防干扰素所致发热的临床效果比单独口服消炎痛或柴胡注射液保留灌肠更好。

Objective To analyze the use of interferon before the first agent given different treatment of interferon- induced fever prevention and observe Indomethacin joint bupleurum injection for preventing the clinical effect of interferon caused by fever. Methods 90 cases of patients with viral hepatitis were randomly divided into experimental group of 30 eases, control 1 group 30 cases and control 2 group of 30 cases. The experimental group was treat with oral indomethacin and bupleurum injection retention enema 30 minutes before interferon treatment. The control 1 group given bupleurum in- jection retention enema and control 2 roup give idomethacin orally. Results The cooling effect of experiment group was better than that of the control 1 group and control 2 group （P〈0.05）. The The cooling effect of the control 1 group and control 2 group were not different （P〈0.05）. Conclusion It is effective to prevent interferon induced fever with indom- ethacin and bupleurum injection.