结核感染T细胞斑点试验及结核抗体在肺外结核病诊断中的临床意义

Clinical value of T-cell enzyme-linked lmmqnospot assay and tuberculosis antibody in the diagnosis of extrapulmonary tuberculosis

目的探讨结核感染T细胞斑点试验(T-SPOT.TB)及抗结核抗体(38kD-IgG)试验在肺外结核病诊断中的临床价值。方法分析入院疑患肺外结核治疗的患者68例,其中确诊结核47例,非结核患者21例。用上述两种方法分别检测68例患者,并将二者的结果进行比较。结果 T-SPOT.TB试验检测确诊结核病人的阳性率为78.7%(37/47)明显高于用结核抗体法检测确诊结核病人的阳性率59.5%(28/47)(P<0.05)。二者的特异度分别为95.2%和71.4%,T-SPOT.TB检测特异度明显高于结核抗体检测(p<0.05)。结论 T-SPOT.TB检测是诊断肺外结核的快速敏感方法,在肺外结核性疾病诊断中有重要价值,可作为临床结核病的有效辅助诊断手段。

Objective To evaluate the application value of T-cell enzyme- linked Immqnospot assay （T-SPOT. TB） and tuberculosis antibody used for clinical diagnosis of extrapulmonary tuberculosis. Methods 69 patients with tubercu- losis were detected with T-cell enzyme- linked Immqnospot assay and tuberculosis antibody. Results The positive rate of T-SPOT. TB was 78.7% （37/47）, which was higher than that of tuberculosis antibody （59. 5%） （P〈0.05）. Conclusion The T- SPOT. TB test has a higher sensitivity and specificity than tuberculosis antibody. It can be used as the effective auxiliary diagnosis methods of extrapulmonary tuberculosis.