芬太尼透皮贴剂联合高频热疗治疗晚期癌痛的临床观察

Clinical Observation of Fentanyl Transdermal Patch Combined with Altofrequency Heat Therapy in the Treatment of Advanced Cancer Pain

目的:观察芬太尼透皮贴剂联合高频热疗治疗晚期癌痛的疗效及安全性。方法:80例晚期癌痛患者按随机数字表法均分为单用组和联合组。单用组患者给予芬太尼透皮贴剂,首次剂量为25μg/h,72 h/次,首次给予芬太尼透皮贴剂12 h内,应继续使用相同剂量的普通吗啡;联合组患者在单用组治疗的基础上给予高频热疗,温度42～43℃,时间为40 min,每次2 d,10次为1个疗程。两组患者均治疗8周。观察两组患者疼痛疗效、芬太尼透皮贴剂剂量变化、生存质量及不良反应发生情况。结果:联合组患者总有效率、生存质量改善率均显著高于单用组,不良反应发生率显著低于单用组,差异均有统计学意义(P<0.05)。两组患者芬太尼透皮贴剂剂量变化率比较差异无统计学意义(P>0.05)。结论:芬太尼透皮贴剂联合高频热疗治疗晚期癌痛疗效显著,且安全性较好。

OBJECTIVE： To observe the therapeutic efficacy and safety of Fentanyl transdermal patches combined with altofrequency heat therapy in the treatment of advanced cancer pain. METHODS： 80 cases of advanced cancer pain were randomly divided into combination group and simple group. Simple group was given Fentanyl transdermal patches with initial dose of 25 μg/h, every 72 hours, at the same time, and give same dose of common morphine. Combination group was additionally given altofrequency heat therapy, at 42-43℃, lasting for 40 min, every other day. A treatment course lasted for 10 times. Both groups were treated for 8 weeks. Therapeutic efficacy, the dose change of Fentanyl transdermal patches, KPS and the occurrence of ADR were observed in 2 groups. RESULTS： The total effective rate quality of life and improvement rate of combination group were significantly higher than those of simple group and the incidence of ADR; there was statistical significance （P〈0.05）. There was no statistical significance in the dose of Fentanyl transdermal patches was lower than simple group between 2 groups （P〉0.05）. CONCLUSIONS： Fentanyl transdermal patches combined with altofrequency heat therapy is effective and safe in the treatment of advanced cancer pain.