氯雷他定联合复方甘草酸苷治疗慢性荨麻疹的成本-效果分析

Cost-effectiveness Analysis of Loratadine Combined with Compound Glycyrrhizin in the Treatment of Chronic Urticaria

目的:评价氯雷他定联合复方甘草酸苷治疗慢性荨麻疹的效果。方法:将120例慢性荨麻疹患者按就诊日期的单双号均分为氯雷他定组和联合用药组。氯雷他定组患者给予氯雷他定10 mg,qd;联合用药组在此基础上加用复方甘草酸苷3片,tid。两组患者疗程均为3周。观察两组患者的疗效及不良反应,并采用成本-效果分析法评价治疗方案。结果:联合用药组患者的总有效率显著高于对照组(90.00%vs.63.33%),且不良反应发生率显著低于氯雷他定组(5.00%vs.38.33%),两组比较差异有统计学意义(P<0.05)。联合用药组的成本-效果比为5.14,高于氯雷他定组(2.81),联合用药组相对于氯雷他定组的增量成本-效果比为10.68。经敏感度分析结果不变。结论:单用氯雷他定治疗慢性荨麻疹更为经济,但在患者条件允许的情况下,应尽量选择与复方甘草酸苷联用,以提高其疗效和安全性。

OBJECTIVE： To evaluate cost-effectiveness of loratadine combined with Compound glycyrrhizin in the treatment of chronic urticaria. METHODS： 120 patients with chronic urticaria were divided into loratadine group and drug combination group ac- cording to odd and even numbers of the date of visiting doctor. Loratadine group was treated with loratadine 10 mg, qd; drug combination group was given 3 tablets of Compound glycyrrhizin, tid, on the basis of loratadine group. Treatment course of 2 groups lasted for 3 weeks. Therapeutic efficacy and adverse drug reactions of 2 groups were observed, and was evaluated by cost-efficacy analysis. RESULTS： The total effective rate of drug combination group was significantly better than that of control group （90.00 % vs. 63.33% ）, the rate of drug combination group was lower than that of control group（5.00% vs. 38.33% ） ; there was statistical significance （P〈0.05）. The cost-effectiveness ratio of drug combination group was 5.14, which was higher than that of loratadine group （2.81）; the incremental cost-effectiveness ratio was 10.68. The sensitivity analysis also showed the same results. CONCLUSIONS： The treatment plan for chronic urticaria of loratadine group is more economical, but under the correct conditions, it is best to choose drug combination plan so as to ensure it＇s efficacy and safety.