尼美舒利致不良反应247例分析

Analysis of 247 Cases of Adverse Drug Reaction of Nimesulide

目的:探讨尼美舒利致不良反应(ADR)的特点及规律,促进临床合理用药。方法:收集通过上海市药品不良反应监测中心2004-2011年自发呈报系统上报的247例尼美舒利致ADR报告,对ADR所涉及的相关情况进行统计、分析。结果:247例ADR中,男性86例,女性161例,女性明显多于男性,且≥50岁患者最多(占61.95%);ADR发生时间以用药1周内最多,占82.19%;报告人以医师最多,占73.28%;临床表现以皮肤及其附件损害为主,占32.48%,其次为消化系统损害,占31.53%;发生严重不良反应10例,其中死亡2例。结论:尼美舒利具有较高的致严重不良反应的风险,应在医师的指导下慎用,严格把握适应证,并依据临床实际情况采用最小的有效剂量、最短的疗程。

OBJECTIVE： To probe into the characteristics and laws of adverse drug reactions （ADR） caused by Nimesulide, promote the rational drug use of Nimesulide. METHODS： 247 reports of adverse reactions caused by Nimesulide were collected from January 2004 to December 2011 and statistically analyzed and statistically analyzed in the respect Of patients＇ sex and age, involved type, result, clinical manifestation etc. RESULTS： Of the 247 cases, 86 were male cases, 161 were female cases, and female was significantly more than male; 61.95% were the adult over the age of 50; ADR mainly occurred within 1 week after medication, accounting for 82.19% ; 73.28% ADR cases were reported by physicians; lesion of skin and appendant was the main ADR （32.48 % ）, followed by digestive system （31.53 % ） ; there were 10 cases of severe ADR, 2 person died. CONCLUSIONS： Nimesulide has a very high risk of adverse reactions, should be under the guidance of doctors and carefully use.Strictly grasp the indications, and based on the clinical actual conditions, using the minimum effective dose, the shortest period of treatment.