依达拉奉注射液联合血塞通注射液治疗多发性大面积脑梗死的临床分析

The Clinical Analysis of the Edaravone Injection Combined with Xuesaitong Injection in the Treatment of Multiple Large Area Cerebral Infarction

目的:探讨依达拉奉注射液联合血塞通注射液治疗多发性大面积脑梗死的临床效果,进一步指导临床治疗。方法:选取本院2007年1月-2012年1月收治的多发性大面积脑梗死患者80例进行研究,按照随机分组原则分为观察组和对照组,每组各40例。对照组患者采用单纯血塞通进行治疗,观察组患者加用依达拉奉注射液联合血塞通注射液进行治疗,对两组患者治疗效果和治疗前后神经功能缺损程度评分进行对比分析。结果:治疗后,观察组患者的治疗显效率、总有效率和神经功能缺损评分与对照组比较差异有统计学意义(P<0.05)。两组患者的不良反应在停药后均自行消失,且未出现严重不良反应,两组不良反应比较差异无统计学意义(P>0.05)。结论:依达拉奉注射液联合血塞通注射液治疗多发性大面积脑梗死,较单纯采用血塞通进行治疗,可以取得更为显著的临床效果,且安全性高,值得在临床进行推广应用。

Objective： To investigate the clinical effect of edaravone injection combined with Xuesaitong injection in the treatment of multiple large area cerebral infarction, to guide clinical treatment. Method： Eighty cases patients of multiple large area cerebral infarction from January 2010 to January 2012 in the hospital were randomly divided into the control group and the treatment group, each group of 40 cases. The control group was treated by Xuesaitong for treatment, and the observation group was treated by edaravone injection combined with Xuesaitong injection. The therapeutic effect and the neurological deficit scores were analyzed after treatment. Result： The markedly effective rate, total effective rate and the neurological deficit score for the patients after treatment in the observation group were all better than those in the control group, and the difference between the two groups were statistically significant （P〈0.05） . The adverse reactions of patients of the two groups were disappeared after drug withdrawal without serious adverse reactions, and the difference between the two groups was no statistically significant （P〉0.05） . Conclusion： Edaravane injection combined with Xuesaitong injection in the treatment of multiple large area cerebral infarction is better than simple use of Xuesaitong for treatment, which can achieve more significant clinicaleffect and high safety, and is worthy of popularization and application in clinical.