索利那新联合坦索罗辛治疗双J管相关症状疗效观察

Effects of solifenacin and tamsulosin for the treatment of double-J stent related symptoms

目的 探讨索利那新联合坦索罗辛对改善双J管相关症状的疗效.方法 79例输尿管镜碎石术后留置双J管患者随机分为治疗组和对照组.对照组常规治疗,治疗组在常规治疗基础上每天加用索利那新5mg及坦索罗辛0.2mg共4周.4周后拔除双J管,同时完成国际前列腺症状评分（IPSS）、生活质量评分（QOL）、视觉模拟评分（VAS）.结果 全部患者完成研究,无严重并发症发生.对照组中IPSS总分、IPSS刺激评分、IPSS储尿评分、QOL评分、VAS评分分别为（13.56±5.10）、（7.23±3.50）、（6.33±2.55）、（2.75±1.26）、（2.88±1.64）,治疗组为（7.26±3.20）、（4.15±2.16）、（3.11±2.07）、（1.40±1.23）、（2.03±1.35）,差异均有统计学意义（P＜0.05）.结论 索利那新联合坦索罗辛能有效改善患者因留置双J管引起的相关症状,提高生活质量.

Objectives To evaluate the efficacy of solifenacin and tamsulosin in improving double-J stent related urinary tract symptoms.Methods A total of 79 patients with double-J stent placement following ureteroscopic lithotripsy were randomized into two groups.The treated group received 5 mg solifenacin and 0.2 mg tamsulosin once daily for 4 weeks,and the control group received routine treatment.All patients were asked to complete the Intemational Prostate Symptom Score（IPSS）,quanlity of life （QOL） and visual analogue scale （VAS） 4 weeks post -operatively when the double-J stent was removed.Results All patients finished the studies.The total IPSS score,irritative IPSS score,obstructive IPSS score,Qol and VAS score were all significantly different between the two groups（P ＜0.05）.Total IPSS score：（13.56 ±5.10） vs（7.26 ±3.20） ; irritative IPSS score：（7.23 ±3.50）vs （4.15 ± 2.16） ; obstructive IPSS score：（6.33 ± 2.55） vs （3.11 ± 2.07） ; QOL：（2.75 ± 1.26） vs （1.40 ± 1.23） ; VAS score：（2.88 ± 1.64） vs （2.03 ± 1.35）.Conclusions Administration of solifenacin and tamsulosin for patients with an interal double-J stent can relieve stent-related symptoms and improve quality of life.