帕罗西汀治疗无精神障碍的功能性胃肠病的临床观察

A clinical trial of paroxetine in treatment of functional gastrointestinal disorders without anxiety and depression

目的观察帕罗西汀治疗无精神障碍的功能性胃肠病患者的临床疗效。方法将89例无精神障碍的功能性胃肠病患者随机分为2组,对照组44例,给予抑制胃酸、保护胃肠黏膜、调节胃肠动力等常规治疗,治疗组45例,在常规治疗的基础上加用帕罗西汀治疗,分别观察2组的治疗效果。结果在治疗4周以后,2组的消化道症状总积分较治疗前均明显下降,治疗组消化道症状总积分的下降比对照组更明显(7.4±6.6 vs.10.7±8.1,P<0.05);治疗后治疗组10例显效,23例有效,治疗组的总有效率明显高于对照组(73.33%vs.52.27%,P<0.05)。结论帕罗西汀是治疗功能性胃肠病有效、安全的精神类药物,对不伴有明确抑郁或焦虑等精神障碍的患者,在内科常规治疗基础上加用帕罗西汀能显著改善症状,提高疗效。

Objective To observe the clinical effects of Paroxetine on the functional gastrointestinal disorders without anx- iety and depression. Methods Eighty-nine patients with functional gastrointestinal disorders without anxiety and depres- sion were selected and divided into treatment group （ n = 45 ） and control group （ n = 44）. The treatment group received routine medicine and Paroxetine ; the control group received routine medicine. After 4 weeks, every patient was made scores of 9 gastrointestinal symptoms and a level of therapeutic efficacy. Results In both groups the scores of 9 gastrointestinal symptoms were all lower after treatment, and the treatment group decreased more significantly than the control group （7.4 ＋ 6.6 vs 10.7 -＋ 8.1 ,P 〈0.05 ）. In the treatment group, 10 cases were significantly effective and 23 cases effective. The effective rate of the treatment group amounted to 73.33% ,was superior to that（52.27% ） of the control group（P 〈 0.05）. Conclusion Paroxetine is an effective and safety psychology drug for the functional gastrointestinal disorders. Ad- ministration of Paroxetine to functional gastrointestinal disorders patients without anxiety and depression can reduce symp- toms and improve therapeutic efficacy.