摘要
目的探讨硝苯地平对先兆早产患者血清CRP、Th1/Th2细胞因子与分泌物fFN、IGFBP-1、HLF的影响。方法选取2011年10月—2013年2月于广西省柳州市柳铁中心医院进行治疗的72例先兆早产患者为研究对象,将其随机分为对照组(硫酸镁组)和观察组(硝苯地平组),每组各36例,然后将2组患者治疗前与治疗后1d、3 d的血清CRP、Th1/Th2细胞因子与分泌物fFN、IGFBP-1、HLF水平进行比较。结果观察组治疗后1 d、3 d的血清CRP、Th1/Th2细胞因子变化大于对照组,分泌物fFN、IGFBP-1低于对照组,HLF高于对照组,P均<0.05,差异均有统计学意义。结论硝苯地平对先兆早产患者血清CRP、Th1/Th2细胞因子与分泌物fFN、IGFBP-1、HLF的影响较大,保胎效果相对较好。
Objective To study the influence of nifedipine on the levels of serum CRP,Thl/Th2 cell factor and secretion fFN, IGFBP-1, HLF in the patients with threatened premature labor. Methods A total of 72 patients with threatened pre- mature labor in our hospital from October 2011 to February 2013 were selected as research object, and they were randomly divided into control group （ magnesium sulfate group） and observation group （ nifedipine group） with 36 cases in each group. The levels of serum CRP, Thl/Th2 cell factor and secretion fFN, IGFBP-1, HLF of both groups before the treatment and at first and third day after the treatment were compared. Results The change of serum CRP,Thl/Th2 cell factor of observation group at first and third day after the treatment were obvious as compared to the control group, secretion fFN and IGFBP-1 were lower than those of control group, HLF were higher than those of control group, there were all signifi- cant differences ,P 〈 0.05. Conclusion The influence of nifedipine on the levels of serum CRP,Thl/Th2 cell factor and secretion fFN, IGFBP-1, HLF in patients with threatened premature labor is obviously, and can dramatically prevent mis- carriage.
出处
《中华全科医学》
2014年第1期83-85,共3页
Chinese Journal of General Practice
