血清脂联素在新生儿缺血缺氧性脑病中的诊疗价值

Analysis of the value of adiponectin in the diagnosis of hypoxic-ischemic encephalopathy

目的探讨血清脂联素是否可以辅助用于新生儿缺血缺氧性脑病的诊疗,以及疾病严重程度的判断。方法分析2011年1月—2013年1月在衢州市妇幼保健院接受治疗的新生儿缺血缺氧性脑病(HIE)患儿的临床资料,另选取25例健康新生儿作为对照组。结果共纳入HIE患儿30例。对照组平均血清脂联素水平显著高于HIE患儿(P<0.05)。HIE患儿随着疾病严重级别的上升,血清脂联素呈现下降趋势。轻度、中度及重度HIE患儿治疗4周后血清脂联素较治疗前均显著升高(P<0.05)。HIE患儿治疗4周后血IL-6水平显著低于治疗前(t=9.317,P<0.001);HIE患儿治疗4周后血CRP水平显著低于治疗前(t=11.450,P<0.001)。HIE患儿血IL-6水平与血清脂联素呈现显著负相关(r=-0.688;P<0.001)。HIE患儿血CRP水平与血清脂联素呈现显著负相关(r=-0.575;P<0.001)。结论血清脂联素随着HIE的严重度增高而升高,其与CRP、IL-6具有负相关性,综合这些指标可用以评估HIE患儿的预后与疗效。

Objective Our prospective study was aimed to analyze the value of adiponeetin in the diagnosis of hypoxie-is- chemic eneephalopathy. Methods Clinical data of patients with hypoxie-isehemie eneephalopathy（HIE） received treat- ment at our hospital from 2011 to 2013 was prospective analyzed and selected 25 healthy newborn as control group. Re- suits A total of 30 HIE patients were prospective analyzed. HIE patients had a lower level of adiponectin than that of control group and when the disease severity classification was higher,the level of adiponectin was lower. HIE patients got a higher level of adiponectin after treatment than before, the difference was statistically significant （P 〈 0.05 ）. After treat- ment, HIE patients got a lower level of CRP than before, the difference was statistically significant （ t = 11. 450, P 〈 0. 001 ）. While HIE patients also got a lower level of IL-6 than before （ t = 11. 450,P 〈 0. 001 ）. We found that IL-6 had a significant negative correlation with adiponeetin（ r = -0.688 ;P 〈 0.001 ） and CRP also had a significant negative corre- lation with adiponeetin （ t = 11. 450, P 〈 0.001 ）. Conclusion Adiponectin combine with IL-6, CRP can be used in diag- nosis and judgment prognosis of hypoxie-isehemie eneephalopathy.