冠心病患血小板α-颗粒膜蛋白测定的临床意义

The clinical significant of platelet α GMP-140 level in coronary heart disease

目的 :探讨血小板α-颗粒膜蛋白 (GMP- 140 )测定在冠心病患者中的临床意义。方法 :选择 131例冠心病患者、30例正常对照者 ,采用酶联免疫吸附双抗体夹心法 (EL ISA) ,测定 GMP- 140含量。结果 :冠心病患者 GMP含量显著多于正常对照组 (P<0 .0 0 1) ;合并 AMI组 GMP含量显著多于无合并症和合并高血压、稳定型心绞痛组 (P<0 .0 1) ;不稳定心绞痛组 GMP含量仅次于 AMI组 ,但二者无显著差异。结论 :冠心病病情愈重 ,GMP含量增多愈显著 。

Objective:To explore the clinical significance of platelet α GMP\|140 level in patients with coronary heart disease(CHD).Methods: Platelet α GMP\|140 were determined in 131 patients with CHD and 30 cases of healthy control by ELISA method.Results:There were statistically significant difference between CHD group and healthy control group( P <0 001) for platelet α GMP\|140 content.Content of plasma platelet α GMP\|140 in AMI group was increased significantly compared control and complicated hypertension,stable angina groups( P <0 01) ,Content of plasma platelet α GMP\|140 in AMI group increased than unstable angina group,but difference of 2 groups was not significant.Conclusion:Platelet α GMP\|140 may as an indicator of diagnosing and predicting prognosis. Author′s address Department of Cardiology,The First Hospital of Sanming,Sanming,Fujian,365000