核医学检查对肥厚性心肌病心电图负向T波机理的探讨

The exploration of mechanism of negative T wave in ECG with hypertrophied cardiomyopathy by nucleus medicine

目的 :探讨肥厚性心肌病 (HCM)心电图负向 T波的机理。方法 :选择正常人 (N组 ) 6人和 HCM病例 18人 ,进行常规心电图、超声心动图、核医学检查。结果 :HCM组在心电图的胸导联上特别在 V3～ 6 处出现明显的负向T波 ,它与心肌肥厚部位有关 ,但范围更大。 HCM组病人心肌各部位均有 1 2 3I-间位碘代苄胍 (1 2 3I- MIBG)摄取率低下 ,与 N组相比有统计学上意义 (P<0 .0 1或 0 .0 5 )。结论 :HCM除肥厚部位外非肥厚部位也出现负向 T波 ,且1 2 3I- MIBG摄取率低下 ,推测 HCM负向

Objective:Hypertrophied cardiomyopathy (HCM) with negative T wave in the electrocardiogram(ECG) was discussed by nucleus medicine.Methods:Eighteen patients with HCM and 6 normal subjects were examinod by ECG,echocardiography and SPECT with 123 I\|MIBG.Results:In HCM group were showed negative T wave in lead V 3～5 of ECG.HCM group showed low activity of 123 I\|MIBG,when compared with normal group ( P <0 05 or P <0 01).Conclusion:The negative T waves in HCM may be due to myocardial hypertrophy and decreased sympathetic never activity. Author′s address Department of Medicine,Xuhui Center Hospital,Shanghai,200031