苯基-(3,5-二叔丁基-4-羟基苄基)丙二酸二(1,2,2,6,6-五甲基-4-哌啶)酯的合成

Synthesis of Bis-( 1,2,2,6,6-pentamethyl-4-piperidinyl) ester Phenyl-( 3,5-di-tertbutyl-4-hydroxybenzyl) malonitic Acid

以苯基丙二酸二乙酯、N-甲基-2,2,6,6-四甲基-4-哌啶醇和2,6-二叔丁基-4-甲基苯酚为主要原料,合成了紫外线吸收剂苯基-(3,5-二叔丁基-4-羟基苄基)丙二酸二(1,2,2,6,6-五甲基-4-哌啶)酯。重点考察了苯基丙二酸二乙酯和N-甲基-2,2,6,6-四甲基-4-哌啶醇的酯交换反应、苯基丙二酸双(1,2,2,6,6-五甲基-4-哌啶)酯与4-羟基-3,5-二叔丁基苄基氯的烃基化反应。结果表明,微纳米碳酸钾具有较好的催化作用,产品总收率达到80%。化合物的结构通过1HNMR和13CNMR进行了表征。

UV absorber bis- （ 1,2,2,6,6-pentamethyl-4-piperidinyl ） ester phenyl- （ 3,5-di-tertbutyl-4- hydroxybenzyl） malonic acid was synthesized from the main raw materials diethyl phenylmalonate and N-methyl-2, 2, 6, 6-tetramethyl-4-piperidinol and 2, 6-di-tertbutyl-4-hydroxyltoluene. The transesterification of diethyl phenylmalonate with N-methyl-2,2,6,6-tetramethyl-4-piperidinol and the alkylation of his- （ 1,2,2,6,6-pentamethyl-4-piperidinyl ） ester phenylmalonic acid with 4-hydroxy-3,5- di-tertbutylbenzyl chloride were investigated. The results show that micronano-K2 CO3 had good catalytic performance,and the optimized overall yield was 80%. The product was characterized by means of 1HNMR and 13 CNMR.