FluG-BrlA途径参与构巢曲霉无性发育机制的研究进展

Advances in studies of FluG-BrlA pathway involved in asexual developmental mechanisms of Aspergillus nidulans

构巢曲霉是丝状真菌的模式生物,已对其无性发育机制进行了比较充分的研究。本文以FluG-BrlA途径参与构巢曲霉无性发育机制的研究为切入点,综述了构巢曲霉无性发育中心调控路径中各主要成员如brlA、abaA、wetA,中心调控路径修饰基因如stuA、medA及中心调控路径激活因子fluG、flbA-E的研究进展,绘制出构巢曲霉无性发育相关基因遗传位置模式图。研究将为其它丝状真菌无性发育机制的研究提供参考。

Aspergillus nidulans is a filamentous fungus used as a model system for asexual developmental mechanisms study. Taking research of the FluG-BrlA pathway involved in Aspergillus nidulans asexual developmental as the starting point, we summarized current understanding of the asexual developmental including the central regulatory pathway genes （brlA, abaA and wetA）, the central regulatory pathway modifiers （stuA and medA） and the central regulatory pathway activators （fluG, flbA？E）, as well as the genetic model for related genes of Aspergillus nidulans conidiation. This review can be used as references for researching asexual developmental mechanisms of other filamentous fungi.