妊高征孕妇的血清尿酸水平与围产儿预后的关系

Relationship between Serum Uric Acid Level and Prenatal Outcome in Pregnancy Induced Hypertension Patients

目的:探讨妊高征孕妇血清尿酸水平对围产儿预后的影响。方法:对248例妊高征孕妇进行血清尿酸(UA)、肌酐(Cr)、尿素氮(BUN)水平测定,并对其围产儿预后进行分析。结果:血清尿酸含量与妊高征严重程度密切相关,与轻、中度妊高征患者相比,重度妊高征患者的尿酸水平增高(均P<0.01)。当尿酸值增高时,胎儿发生宫内生长迟缓(IUGR)、胎死宫内、胎儿宫内窘迫及新生儿病死率显著增高。尿酸值愈高,围产儿预后愈差。结论:妊高征孕妇的血清尿酸值与围产儿预后密切相关,可作为判断围产儿预后及终止妊娠的一项参考指标。

To investigate the effect of serum uric acid concentration on prenatal outcome in pregnancy induced hypertension (PIH) patients. Methods:Serum uric acid (UA) ,creatinine (Cr) and urea nitrogen (BUN) were measured in 248 PIH patients. The prenatal prognosis was analyzed. Results: Serum UA concentration was closely related to the degree of PIH. The level of UA in severe PIH patients was significantly higher than in mild and moderate PIH patients ( P <0.01, P <0.01) . When UA levels rose,the incidences of intrauterine growth retardation,dead fetus,intrauterine distress and newborn mortality increased significantly. The higher the UA level was, the worse the prenatal prognosis was. Conclusion: In PIH patients, the serum UA level is closely related to the prenatal outcome. It can be used to assess the prenatal prognosis and as an index to terminate gestation appropriately.