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自噬与淋巴瘤细胞的生存 被引量：1

Autophagy and lymphoma cell survival
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摘要 自噬在肿瘤的发生发展中发挥着不同作用，可能起着致病的作用，也可能起到保护作用。淋巴瘤是一类复杂多变的肿瘤，自噬可以降低淋巴瘤化疗的效果，抑制自噬成为淋巴瘤治疗的新靶点。免疫相关性GTP酶免疫相关GIP酶家族成员1是自噬途径的重要调节分子，其在维持淋巴细胞的生存中起到非常重要的作用，为此探讨免疫相关GTP酶家族成员1（IRGM1）在淋巴瘤细胞发生发展中的作用可能为揭示淋巴瘤的发生机制及治疗提供新的思路。 Autophagy may play a dual role in cancer development, the pathogenic one and the protective one. Lymphoma is a class of complex tumors, autophagy can reduce the effect of chemotherapy, and inhibiting autophagy becomes a new target for the treatment of lymphoma. Immune-related GTP enzyme（ IRGM1 ）is an important regulator molecule in autophagy pathway, playing a very important role in maintaining the survival of lymphocytes. The study of IRGM 1 in survival and development of lymphoma cells may provide new ideas of revealing mechanisms and therapy of lymphoma.
作者 程海荣 姜鹏宇 裴春颖 徐红薇
机构地区 哈尔滨医科大学免疫教研室
出处 《国际免疫学杂志》 CAS 2014年第1期17-21,共5页 International Journal of Immunology
基金 国家自然科学基金面上项目（81071949） 黑龙江省自然科学基金面上项目（D201004）
关键词 自噬 淋巴瘤 免疫相关GIP酶家族成员1 Autophagy Lymphocyte Immune-related GTP enzyme 1
分类号 R392 [医药卫生—免疫学]
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参考文献42

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同被引文献19

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国际免疫学杂志
2014年 第1期

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