静脉溶栓对急性心肌梗死EKG校正的QT间期离散度的影响

Effect of Intravenous Thrombolytic Treatment on QT Corrected Dispersion in Acute Myocardial Infarction

目的:探讨急性心肌梗死(AMI)静脉溶栓治疗对校正的QT间期离散度(QTcd)的影响。方法:用体表心电图同步12导联测量64例AMI患者溶栓前及溶栓后3小时的QTcd,并对出现与未出现恶性心律失常者的QTcd进行比较。设30例正常人做对照组,取其QTcd作为参考值。结果AMI组溶栓前与对照组QTcd差异有显著性(P<0.01),溶栓后再通组QTcd时限缩短,而未通组QTcd时限无明显变化,两者的QTcd差异有显著性(P<0.01)。出现恶性心律失常的AMI患者,其QTcd长于不出现者。结论:成功的溶栓治疗可使QTcd缩短,亦可减少恶性心律失常的发生。

Objective:To investigate the effect of intravenous thrombolytic treatment on QT corrected dispersion (QTcd) in acute myocardial infarction (AMI). Methods:QTcd were measured in 64 AMI patients using synchronous 12 lead electrocardiograph pre and 3 hours post intravenous thrombolytic treatment. QTcd were compared in patients with and without fatal arrhythmia. Thirty healthy persons were in control group. Results: There was a significant difference in QTcd between AMI and control group before treatment (P<0.01). QTcd significantly shortened in reperfusion group after thrombolytic treatment , and there was no significant change of QTcd in non-perfusion group. There was a significant difference of QTcd between this two groups (P<0.01). QTcd were longer in patients with fatal arrhythmia than that in patients without fatal arrhythmia.Conclusion:Shortened QTcd and low incidence of fatal arrhythmia can be obtained by successful thrombolytic treatment in AMI.